Scenario 1: Biosafety Laboratory (BSL) Level 4
This particular blog post is in reference to BSL 4. The code of practice and protocols for BSL 1 and 2 still applies for BSL 4, but certain modifications are made and as follows:Biosafety Level 4 (BS-4)
- Required for work with dangerous and exotic agents that pose a high individual risk of aerosol-transmitted laboratory infections and life-threatening disease.
- Until ample data are obtained either to confirm continued work at this level, or to work with them at a lower level, agents with a close or identical antigenic relationship to Biosafety Level 4 agents are handled at this level.
- Laboratory staff undergo specific and extensive training in handling extremely hazardous infectious agents to understand the primary and secondary containment functions of the standard and special practices, the containment equipment, and the laboratory design characteristics. Skillful scientists who are trained and experienced are tasked to supervise them.
- The laboratory director strictly controls access to the laboratory. The facility should be completely isolated from all other areas of the building, either in a separate building or in a controlled area within a building.
- A specific facility operations manual is prepared or appointed. All activities are confined to Class III biological safety cabinets within work areas of the facility. Class II biological safety cabinets ventilated by a life support system is used with one-piece positive pressure personnel suits.
- The unique engineering and design features prevent microorganisms from being transmitted into the environment.
References:
DiBerardinis, L. J., Gatwood, G. T., Baum, J. S., Groden, E. F., First, M. W. & Seth, A. K. (1993) Guidelines for Laboratory Design: Health and Safety Considerations. (2nd ed.). NY: John Wiley & Sons, Inc.
Furr, A. K. (2000) CRC Handbook of Laboratory Safety. (5th ed.). FL: CRC Press.
IUPAC-IPCS (1992) Chemical Safety Matters. UK: Cambridge University Press
Jackson, L. (Executive Producer), & Alboum, S. (Producer, Director). (2008). The Chem Lab: Safety in Every Step. [Motion Picture]. Princeton, NJ: Films for the Humanities & Sciences.
Leonard, D. (n.d.). Elements of Safety: Orientation to Laboratory Safety. [VCD] Singapore:SafetyMax Corp. Pte Ltd.
Safety Sense: A Laboratory Guide. (2nd ed.). (2007) USA, NY: Cold Spring Harbour Laboratory Press.
Salerno, R. M. & Gaudioso, J. (2007) Laboratory Biosafety Handbook. Boca Raton, FL: CRC Press, Taylor & Francis Group
University of Colorado. (2011). Laboratory Safety. Retrieved from http://orgchem.colorado.edu/safety/labsafety.html
World Health Organization. (2004). Laboratory Biosafety Manual (3rd ed.). Retrieved from WHO, Geneva: http://www.who.int/csr/resources/publications/biosafety/Biosafety7.pdf
Labels: BSL 4
posted by Michelle, Bernadette, Shanna, Karen, Su Wei, Shi Ting @ 16:33
0 Comments:
Post a Comment
Subscribe to Post Comments [Atom]
<< Home